1043-3155 Pediatr Neurol Briefs pedneurbriefs Pediatr Neurol Briefs Pediatric Neurology Briefs Pediatr Neurol Briefs 2166-6482 1043-3155 2166-3155 Pediatric Neurology Briefs Publishers Chicago, IL, USA PNB-2-18-a 10.15844/pedneurbriefs-2-3-3 Congenital Malformations Neurology Pediatrics Nervous System Diseases Child Development Brain Diseases Neurosurgery Child Infant Fragile-X Syndrome http://orcid.org/0000-0002-0173-7931 Millichap J. Gordon MD 1 2 * Division of Neurology, Children's Memorial Hospital, Chicago, IL Departments of Pediatrics and Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL Correspondence: Dr. J. Gordon Millichap, E-mail: jgmillichap@northwestern.edu 03 1988 01 08 2016 2 3 18 18 Copyright: © 1988 The Author(s) 1988 This work is licensed under the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Fragile-X syndrome: a particular epileptogenic EEG pattern

A characteristic epileptogenic EEG pattern is described in five of 12 male subjects with fragile-X syndrome evaluated at the Instituto Oasi, via C. Ruggero, Troina, Italy, and Clinica Neurologica, II Universita Roma and Bologna, Italy.

 Fragile-X Syndrome Mental Retardation Karyotyping

A characteristic epileptogenic EEG pattern is described in five of 12 male subjects with fragile-X syndrome evaluated at the Instituto Oasi, via C. Ruggero, Troina, Italy, and Clinica Neurologica, II Universita Roma and Bologna, Italy. Focal paroxysmal temporal spikes, at times multifocal, occurred in sleep in one non-epileptic and four epileptic patients with mental retardation and fragile-X syndrome, but not in subjects with mental retardation, with or without epilepsy but without the fragile-X chromosome. [1]

COMMENT. The authors believe that epilepsy must be considered an important clinical feature of fragile-X syndrome, occurring in an average of 26% of reported cases. Karyotyping is advised in mentally retarded patients with epilepsy, even in those without typical clinical features or positive family history and especially in children who frequently lack the characteristic facial dysmorphisms and macro-orchidism (see Ped Neur Briefs 1987;1:41).

 Musumeci SA Colognola RM Ferri R Gigli GL Petrella MA Sanfilippo S Fragile-X syndrome: a particular epileptogenic EEG pattern Epilepsia 1988 Jan-Feb 29 1 41 7 10.1111/j.1528-1157.1988.tb05096.x 3338421