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<front>
<journal-meta>
<journal-id journal-id-type="issn">1043-3155</journal-id>
<journal-id journal-id-type="nlm-ta">Pediatr Neurol Briefs</journal-id>
<journal-id journal-id-type="pmc">pedneurbriefs</journal-id>
<journal-id journal-id-type="iso-abbrev">Pediatr Neurol Briefs</journal-id>
<journal-title-group>
<journal-title>Pediatric Neurology Briefs</journal-title>
<abbrev-journal-title>Pediatr Neurol Briefs</abbrev-journal-title>
</journal-title-group>
<issn pub-type="epub">2166-6482</issn>
<issn pub-type="ppub">1043-3155</issn>
<issn-l>2166-3155</issn-l>
<publisher>
<publisher-name>Pediatric Neurology Briefs Publishers</publisher-name>
<publisher-loc>Chicago, IL, USA</publisher-loc>
</publisher>
</journal-meta>
<article-meta>
<article-id pub-id-type="publisher-id">PNB-2-80</article-id>
<article-id pub-id-type="doi">10.15844/pedneurbriefs-2-10-12</article-id>
<article-categories>
<subj-group subj-group-type="heading">
<subject>Behavior and Learning Disabilities</subject>
</subj-group>
<subj-group subj-group-type="Discipline-v2">
<subject>Neurology</subject>
<subject>Pediatrics</subject>
<subject>Nervous System Diseases</subject>
<subject>Child Development</subject>
<subject>Brain Diseases</subject>
<subject>Neurosurgery</subject>
<subject>Child</subject>
<subject>Infant</subject>
</subj-group>
</article-categories>
<title-group>
<article-title>Autistic Spectrum Disorder</article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author" corresp="yes">
<contrib-id contrib-id-type="orcid">http://orcid.org/0000-0002-0173-7931</contrib-id>
<name>
<surname>Millichap</surname>
<given-names>J. Gordon</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="AF0001">1</xref>
<xref ref-type="aff" rid="AF0002">2</xref>
<xref ref-type="corresp" rid="cor1">&#x002A;</xref>
</contrib>
</contrib-group>
<aff id="AF0001">
<label>1</label>Division of Neurology, Children&#x0027;s Memorial Hospital, Chicago, IL</aff>
<aff id="AF0002">
<label>2</label>Departments of Pediatrics and Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL</aff>
<author-notes>
<corresp id="cor1"><label>&#x002A;</label>Correspondence: Dr. J. Gordon Millichap, E-mail: <email xlink:href="jgmillichap@northwestern.edu">jgmillichap@northwestern.edu</email>
</corresp>
</author-notes>
<pub-date date-type="pub" publication-format="print">
<month>11</month>
<year>1988</year>
</pub-date>
<pub-date date-type="pub" publication-format="electronic">
<day>01</day>
<month>08</month>
<year>2016</year>
</pub-date>
<volume>2</volume>
<issue>10</issue>
<fpage>80</fpage>
<lpage>80</lpage>
<permissions>
<copyright-statement>Copyright: &#x00A9; 1988 The Author(s)</copyright-statement>
<copyright-year>1988</copyright-year>
<license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/4.0/">
<license-p>This work is licensed under the <uri xlink:href="http://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution 4.0 International License</uri>, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
</license>
</permissions>
<related-article id="R1" related-article-type="commentary-article" ext-link-type="pmid" xlink:href="2459962" vol="142" page="1178">
<article-title>Disorders of higher cerebral function in preschool children. Second of two parts</article-title>
</related-article>
<abstract abstract-type="web-summary" specific-use="electronic-only">
<p>In the second part of an excellent review of disorders of higher cerebral function, Dr. Isabelle Rapin, at the Albert Einstein College of Med, Bronx, NY, outlines the evaluation and management of preschool children with autism and inadequate communication skills.</p>
</abstract>
<kwd-group>
<kwd>Autistic Spectrum Disorder</kwd>
<kwd>Cerebellar Hypoplasia</kwd>
<kwd>Fragile X Syndrome</kwd>
</kwd-group>
</article-meta>
</front>
<body>
<p>In the second part of an excellent review of disorders of higher cerebral function, Dr. Isabelle Rapin, at the Albert Einstein College of Med, Bronx, NY, outlines the evaluation and management of preschool children with autism and inadequate communication skills. The core symptoms of the autistic spectrum disorder are listed as follows: 1) impaired socialization, 2) inadequately modulated affect, 3) language disorder always affecting communicative skills and comprehension, and 4) abnormal play with a narrow range of interests. There is a spectrum of autistic disorders, ranging from mute, withdrawn individuals with motor stereotypes to highly verbose persons with perseveration, insistence of routines and sameness, and overspecialized interests such as dictionaries, train schedules, and calendars. Autism usually denotes a static condition. The most efficient way to evaluate communication skills is to observe the child at play, to talk to him, and to ask questions about his play. Children who manipulate toys rather than play with them, who talk to themselves, or who are echolalic or perseverative are almost certainly abnormal. Hearing tests, speech and language evaluation, neuropysychological tests, and consultations with child neurologist and psychiatrist may be required before referral to a preschool specialized program. [<xref ref-type="bibr" rid="CIT0001">1</xref>]</p>
<disp-quote>
<p>COMMENT. Cerebellar hypoplasia and autism is discussed in the correspondence section of [<xref ref-type="bibr" rid="CIT0002">2</xref>]. Patients with autism, mean age 20 yr, were reported to have a decrease in the size of cerebellar vermal lobules VI and VII on MRI scans. These findings were not confirmed in one study of 15 patients with autism (mean age 11.5 years) compared to 15 normal matched controls, but they were replicated in a study of men with fragile X syndrome, a condition sometimes associated with autism. Investigations that include children as well as adults would help to specify whether the observed cerebellar changes or MRI are actually hypoplasia on atrophy occurring postnatally.</p>
</disp-quote>
</body>
<back>
<ref-list>
<ref id="CIT0001">
<label>1</label>
<element-citation publication-type="journal">
<person-group person-group-type="author">
<name>
<surname>Rapin</surname>
<given-names>I</given-names>
</name>
</person-group>
<article-title>Disorders of higher cerebral function in preschool children. Second of two parts</article-title>
<source>Am J Dis Child</source>
<year>1988</year>
<month>Nov</month>
<volume>142</volume>
<issue>11</issue>
<fpage>1178</fpage>
<lpage>82</lpage>
<pub-id pub-id-type="pmid">2459962</pub-id>
</element-citation>
</ref>
<ref id="CIT0002">
<label>2</label>
<element-citation publication-type="journal">
<article-title>Cerebellar hypoplasia and autism</article-title>
<source>N Engl J Med</source>
<year>1988</year>
<volume>319</volume>
<month>Oct</month>
<day>27</day>
<issue>17</issue>
<fpage>1152</fpage>
<lpage>4</lpage>
<pub-id pub-id-type="doi">10.1056/NEJM198810273191709</pub-id>
<pub-id pub-id-type="pmid">3173446</pub-id>
</element-citation>
</ref>
</ref-list>
</back>
</article>
