1043-3155 Pediatr Neurol Briefs pedneurbriefs Pediatr Neurol Briefs Pediatric Neurology Briefs Pediatr Neurol Briefs 2166-6482 1043-3155 2166-3155 Pediatric Neurology Briefs Publishers Chicago, IL, USA PNB-17-40-a 10.15844/pedneurbriefs-17-5-8 Neuromuscular Disorders Neurology Pediatrics Nervous System Diseases Child Development Brain Diseases Neurosurgery Child Infant Long-Term Outcome in Guillain-Barre Syndrome http://orcid.org/0000-0002-0173-7931 Millichap J. Gordon MD 1 2 * Division of Neurology, Children's Memorial Hospital, Chicago, IL Departments of Pediatrics and Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL Correspondence: Dr. J. Gordon Millichap, E-mail: jgmillichap@northwestern.edu 05 2003 01 03 2016 17 5 40 40 Copyright: © 2003 The Author(s) 2003 This work is licensed under the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Long-term outcome in children with Guillain-Barré syndrome

The long-term sequelae and early predictors of sequelae were determined in a chart review of 47 children with Guillain-Barre syndrome (GBS) of whom 30 had been treated with intravenous gammaglobulin (IVIG) at The Hospital for Sick Children, Toronto, Canada.

 Guillain-Barre Syndrome Intravenous Gammaglobulin Long-Term Muscle

The long-term sequelae and early predictors of sequelae were determined in a chart review of 47 children with Guillain-Barre syndrome (GBS) of whom 30 had been treated with intravenous gammaglobulin (IVIG) at The Hospital for Sick Children, Toronto, Canada. Persisting long-term muscle weakness at least 2 years after recovery was present in 23% of cases. Weakness was mild and patients were functionally independent. Risk factors for long-term muscle weakness were a young age at onset and a rapid progression to maximal weakness in the acute illness (P=0.03). [1]

COMMENT. Age associated changes in the symptomatology of GBS in children have been reported previously (Sakakihara Y, Kamoshita S. 1991, see Progress in Poediatric Neurology II, PNB Publ, 1994;pp271-2). Children between 3 and 9 years are most susceptible, and the total duration of the illness is longer in younger children. Bulbar nerves are most frequently affected in the younger age group, and the facial nerve in older patients. The stage of myelinogenic maturation might explain the age-associated changes in symptomatology of GBS.

Vajsar J Fehlings D Stephens D Long-term outcome in children with Guillain-Barré syndrome J Pediatr 2003 Mar 142 3 305 9 10.1067/mpd.2003.115 12640380