1043-3155 Pediatr Neurol Briefs pedneurbriefs Pediatr Neurol Briefs Pediatric Neurology Briefs Pediatr Neurol Briefs 2166-6482 1043-3155 2166-3155 Pediatric Neurology Briefs Publishers Chicago, IL, USA PNB-16-32-a 10.15844/pedneurbriefs-16-4-11 Attention Deficit and Learning Disorders Neurology Pediatrics Nervous System Diseases Child Development Brain Diseases Neurosurgery Child Infant Treatment of ADHD in Neurofibromatosis Type 1 http://orcid.org/0000-0002-0173-7931 Millichap J. Gordon MD 1 2 * Division of Neurology, Children's Memorial Hospital, Chicago, IL Departments of Pediatrics and Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL Correspondence: Dr. J. Gordon Millichap, E-mail: jgmillichap@northwestern.edu 04 2002 01 04 2016 16 4 32 32 Copyright: © 2002 The Author(s) 2002 This work is licensed under the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Treatment of ADHD in neurofibromatosis type 1

The cognitive and behavioral problems and effects of treatment of attention deficit hyperactivity disorder (ADHD) in 20 children with NF1 and ADHD were compared to 26 control children with NF1, 14 controls with ADHD, and 14 controls with normal development, studied at Klinikum Nord Ochsenzoll. Hamburg, Germany.

 Attention Deficit Hyperactivity Disorder Tests of Variables of Attention Child Behavior Checklist

The cognitive and behavioral problems and effects of treatment of attention deficit hyperactivity disorder (ADHD) in 20 children with NF1 and ADHD were compared to 26 control children with NF1, 14 controls with ADHD, and 14 controls with normal development, studied at Klinikum Nord Ochsenzoll. Hamburg, Germany. Of 93 children with NF1 followed at the clinic, 46 had ADHD. Among the 4 groups, children with NF1 and ADHD had the lowest IQ scores. Tests of Variables of Attention (TOVA) scores were lower in the NF1/ADHD and ADHD control groups than in the non-ADHD groups. Scores on the Child Behavior Checklist (CBCL) were significantly poorer for the NF1/ADHD group than the NF1 control group. Low dose (5-15 mg) methylphenidate administered to the NF1/ADHD group significantly improved TOVA scores and CBCL scores. [1]

COMMENT. NF1 is associated with a 50% incidence of ADHD, and learning and social problems in children with NF1 are correlated with ADHD. Stimulant medication in children with NF1/ADHD may improve their cognitive, attention, impulsive, and social problems.

Mautner VF Kluwe L Thakker SD Leark RA Treatment of ADHD in neurofibromatosis type 1 Dev Med Child Neurol 2002 Mar 44 3 164 170 10.1017/S0012162201001876 12005317