1043-3155 Pediatr Neurol Briefs pedneurbriefs Pediatr Neurol Briefs Pediatric Neurology Briefs Pediatr Neurol Briefs 2166-6482 1043-3155 2166-3155 Pediatric Neurology Briefs Publishers Chicago, IL, USA PNB-14-69-a 10.15844/pedneurbriefs-14-9-8 Neuroectodermal Disorders Neurology Pediatrics Nervous System Diseases Child Development Brain Diseases Neurosurgery Child Infant Neurofibromatosis 1 and Growth Hormone Deficiency http://orcid.org/0000-0002-0173-7931 Millichap J. Gordon MD 1 2 * Division of Neurology, Children's Memorial Hospital, Chicago, IL Departments of Pediatrics and Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL Correspondence: Dr. J. Gordon Millichap, E-mail: jgmillichap@northwestern.edu 09 2000 01 04 2016 14 9 69 69 Copyright: © 2000 The Author(s) 2000 This work is licensed under the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Growth hormone deficiency in children with neurofibromatosis type 1 without suprasellar lesions

The growth profiles and growth hormone levels of children with neurofibromatosis 1 (NF-1) were analyzed at the University of Texas Medical School, Houston, TX.

 Neurofibromatosis 1 Growth Hormone Deficiency Organic Pituitary Lesions

The growth profiles and growth hormone levels of children with neurofibromatosis 1 (NF-1) were analyzed at the University of Texas Medical School, Houston, TX. Of 251 children attending the clinic with NF-1, 112 were at or below the 25th percentile for height. Of these, 51 were showing poor growth rates, without radiological evidence of suprasellar lesions. Growth hormone deficiency (GHD), with peak GH levels of less than 5 ng/ml, was determined in 15 of 19 tested. [1]

COMMENT. Growth hormone deficiency and short stature may be associated with neurofibromatosis 1, independent of organic pituitary lesions.

Vassilopoulou-Sellin R Klein MJ Slopis JK Growth hormone deficiency in children with neurofibromatosis type 1 without suprasellar lesions Pediatr Neurol 2000 May 22 5 355 358 10.1016/S0887-8994(00)00123-5 10913726