1043-3155 Pediatr Neurol Briefs pedneurbriefs Pediatr Neurol Briefs Pediatric Neurology Briefs Pediatr Neurol Briefs 2166-6482 1043-3155 2166-3155 Pediatric Neurology Briefs Publishers Chicago, IL, USA PNB-14-70-b 10.15844/pedneurbriefs-14-9-11 Muscle Disorders Neurology Pediatrics Nervous System Diseases Child Development Brain Diseases Neurosurgery Child Infant Acetazolamide in Hypokalemic Periodic Paralysis http://orcid.org/0000-0002-0173-7931 Millichap J. Gordon MD 1 2 * Division of Neurology, Children's Memorial Hospital, Chicago, IL Departments of Pediatrics and Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL Correspondence: Dr. J. Gordon Millichap, E-mail: jgmillichap@northwestern.edu 09 2000 01 04 2016 14 9 70 70 Copyright: © 2000 The Author(s) 2000 This work is licensed under the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Acetazolamide opens the muscular KCa channel: a novel mechanism of action that may explain the therapeutic effect of the drug in hypokalemic periodic paralysis

The mechanism of action of acetazolamide in the K-deficient diet rat, an animal model of human hypokalemic periodic paralysis (hypoPP), was investigated at the University of Bari, Italy.

 Acetazolamide Hypokalemic Periodic Paralysis Sarcolemma

The mechanism of action of acetazolamide in the K-deficient diet rat, an animal model of human hypokalemic periodic paralysis (hypoPP), was investigated at the University of Bari, Italy. In vivo administration of acetazolamide prevented paralysis and depolarization of the fibers induced by insulin. Intense sarcolemma Ca-activated K channel activity was recorded in the acetazolamide-treated animals. The serum K levels were also restored to normal by acetazolamide. [1]

COMMENT. The observed therapeutic effect of acetazolamide in hypokalemic periodic paralysis may be mediated by the activation of the muscular KCa channel.

Tricarico D Barbieri M Camerino Dc Acetazolamide opens the muscular KCa channel: a novel mechanism of action that may explain the therapeutic effect of the drug in hypokalemic periodic paralysis Ann Neurol 2000 Sep 48 3 304 312 10.1002/1531-8249(200009)48:3<304::AID-ANA4>3.0.CO;2-A 10976636