1043-3155 Pediatr Neurol Briefs pedneurbriefs Pediatr Neurol Briefs Pediatric Neurology Briefs Pediatr Neurol Briefs 2166-6482 1043-3155 2166-3155 Pediatric Neurology Briefs Publishers Chicago, IL, USA PNB-14-51-b 10.15844/pedneurbriefs-14-7-5 Antiepileptic Therapy Neurology Pediatrics Nervous System Diseases Child Development Brain Diseases Neurosurgery Child Infant IV Valproate in Refractory Status Epilepticus http://orcid.org/0000-0002-0173-7931 Millichap J. Gordon MD 1 2 * Division of Neurology, Children's Memorial Hospital, Chicago, IL Departments of Pediatrics and Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL Correspondence: Dr. J. Gordon Millichap, E-mail: jgmillichap@northwestern.edu 07 2000 01 04 2016 14 7 51 51 Copyright: © 2000 The Author(s) 2000 This work is licensed under the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Intravenous valproate in pediatric epilepsy patients with refractory status epilepticus

The results of treatment of refractory status epilepticus (SE) with IV valproate (VPA) in 41 children are reported from University Hospital for Children, Erlangen, Germany.

 Refractory Status Epilepticus with IV Valproate Diazepam Phenobarbital

The results of treatment of refractory status epilepticus (SE) with IV valproate (VPA) in 41 children are reported from University Hospital for Children, Erlangen, Germany. Twenty two patients had previously received long-term antiepileptic therapy, whereas the SE was the initial presentation of a seizure disorder in 19. Initial treatment with diazepam, phenobarbital, and phenytoin had failed. The initial loading dose of IV VPA was 20 to 40 mg/kg/body weight, diluted 1:1 with normal saline or 5% dextrose, and given over 1 to 5 minutes, repeated after 10 to 15 minutes if necessary. When seizures had ceased for 12 hours and the EEG was normalized, VPA dosage was reduced.

The response rate was 78%, 66% being controlled within 2 to 6 minutes. The highest success rate was obtained with dosages between 30 and 40 mg/kg/bwt, and correlated with higher VPA blood levels in immediate responders (121 +/- 10 mg/L) compared to levels of 93 +/- 6 mg/L in delayed responders. There were no VPA-related systemic side effects. [1]

COMMENT. IV valproate is an effective and well tolerated alternative therapy for refractory status epilepticus in children.

Uberall MA Trollmann R Wunsiedler U Wenzel D Intravenous valproate in pediatric epilepsy patients with refractory status epilepticus Neurology 2000 Jun 13 54 11 2188 2189 10.1212/WNL.54.11.2188-a 10851397