1043-3155 Pediatr Neurol Briefs pedneurbriefs Pediatr Neurol Briefs Pediatric Neurology Briefs Pediatr Neurol Briefs 2166-6482 1043-3155 2166-3155 Pediatric Neurology Briefs Publishers Chicago, IL, USA PNB-14-28-b 10.15844/pedneurbriefs-14-4-7 Seizure Disorders Neurology Pediatrics Nervous System Diseases Child Development Brain Diseases Neurosurgery Child Infant High-Dose IV Steroids in Landau-Kleffner Syndrome http://orcid.org/0000-0002-0173-7931 Millichap J. Gordon MD 1 2 * Division of Neurology, Children's Memorial Hospital, Chicago, IL Departments of Pediatrics and Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL Correspondence: Dr. J. Gordon Millichap, E-mail: jgmillichap@northwestern.edu 04 2000 01 04 2016 14 4 28 29 Copyright: © 2000 The Author(s) 2000 This work is licensed under the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Effects of high-dose intravenous corticosteroid therapy in Landau-Kleffner syndrome

Intravenous therapy with methylpredisolone (20 mg/kg daily) was effective in two six-year-old children with Landau-Kleffner syndrome treated at Jichi Medical School, Tochigi, Japan.

 High-Dose IV Corticosteroids Landau-Kleffner Syndrome Benzodiazepine

Intravenous therapy with methylpredisolone (20 mg/kg daily) was effective in two six-year-old children with Landau-Kleffner syndrome treated at Jichi Medical School, Tochigi, Japan. A combination of valproate and a benzodiazepine had previously resulted in decreased seizures and EEG improvement, but speech and language were not improved. After 3 consecutive daily treatments with high-dose IV corticosteroids, speech was increased and receptive language improved. After a third course of therapy, the children could speak in sentences, and their subsequent language development was sustained. [1]

COMMENT. High-dose corticosteroid therapy, administered early at the first appearance of symptoms, has been recommended in previous reports (Progress in Pediatric Neurology II, PNB Publ, 1994;pp221-226). [2, 3]

Tsuru T Mori M Mizuguchi M Momoi MY Effects of high-dose intravenous corticosteroid therapy in Landau-Kleffner syndrome Pediatr Neurol 2000 Feb 22 2 145 147 10.1016/S0887-8994(99)00127-7 10738922 Marescaux C Hirsch E Finck S Maquet P Schlumberger E Sellal F Landau-Kleffner syndrome: a pharmacologic study of five cases Epilepsia 1990 Nov-Dec 31 6 768 777 10.1111/j.1528-1157.1990.tb05518.x 1700953 Lerman P Lerman-Sagie T Kivity S Effect of early corticosteroid therapy for Landau-Kleffner syndrome Dev Med Child Neurol 1991 Mar 33 3 257 260 10.1111/j.1469-8749.1991.tb05115.x 1709123