1043-3155 Pediatr Neurol Briefs pedneurbriefs Pediatr Neurol Briefs Pediatric Neurology Briefs Pediatr Neurol Briefs 2166-6482 1043-3155 2166-3155 Pediatric Neurology Briefs Publishers Chicago, IL, USA PNB-13-63-b 10.15844/pedneurbriefs-13-8-11 Neurobehavioral Disorders Neurology Pediatrics Nervous System Diseases Child Development Brain Diseases Neurosurgery Child Infant Neurobehavioral Risk Factors in Schizophrenia http://orcid.org/0000-0002-0173-7931 Millichap J. Gordon MD 1 2 * Division of Neurology, Children's Memorial Hospital, Chicago, IL Departments of Pediatrics and Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL Correspondence: Dr. J. Gordon Millichap, E-mail: jgmillichap@northwestern.edu 08 1999 01 05 2016 13 8 63 64 Copyright: © 1999 The Author(s) 1999 This work is licensed under the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Neurobehavioral deficits at adolescence in children at risk for schizophrenia: The Jerusalem Infant Development Study

Neurobehavioral deficits in the offspring of schizophrenic parents compared to offspring of parents with no or nonschizophrenic mental disorder were analyzed in 65 Israeli adolescents enrolled in the Jerusalem Infant Development Study.

 Neurobehavioral Deficits Nonschizophrenic Mental Disorder Neuropsychological Tests

Neurobehavioral deficits in the offspring of schizophrenic parents compared to offspring of parents with no or nonschizophrenic mental disorder were analyzed in 65 Israeli adolescents enrolled in the Jerusalem Infant Development Study. Poor neurobehavioral functioning, assessed by a battery of neurologic and neuropsychological tests and psychiatric interviews, was found in 42% (10/24) of offspring of schizophrenic parents (73% of the male offspring), compared to 22% (9/41) of offspring of nonschizophrenic parents. Poor psychiatric adjustment at adolescence was preceeded by problems at an earlier age. [1]

COMMENT. Neurobehavioral signs in infants, children and adolescents may be markers of vulnerability to schizophrenia and poor global psychiatric adjustment. Risk factors for development of schizophrenia in offspring of schizophrenics include motor and sensorimotor behavior problems during the first year of life and poor motor and cognitive functioning during school age. Male offspring are more susceptible than girls.

Chromosome anomaly in autism and epilepsy. A 12-year-old boy with atypical autism and epilepsy had a maternally derived duplication of chromosome 15qll-ql3. [2]

Hans SL Marcus J Nuechterlein KH Asarnow RF Styr B Auerbach JG Neurobehavioral deficits at adolescence in children at risk for schizophrenia: The Jerusalem Infant Development Study Arch Gen Psychiatry 1999 Aug 56 8 741 8 10.1001/archpsyc.56.8.741 10435609 Gurrieri F Battaglia A Torrisi L Tancredi R Cavallaro C Sangiorgi E Pervasive developmental disorder and epilepsy due to maternally derived duplication of 15q11-q13 Neurology 1999 May 12 52 8 1694 7 10.1212/WNL.52.8.1694 10331703