1043-3155 Pediatr Neurol Briefs pedneurbriefs Pediatr Neurol Briefs Pediatric Neurology Briefs Pediatr Neurol Briefs 2166-6482 1043-3155 2166-3155 Pediatric Neurology Briefs Publishers Chicago, IL, USA PNB-12-64-a 10.15844/pedneurbriefs-12-8-12 Developmental Disorders Neurology Pediatrics Nervous System Diseases Child Development Brain Diseases Neurosurgery Child Infant Absent Labial Frenulum in Holoprosencephaly http://orcid.org/0000-0002-0173-7931 Millichap J. Gordon MD 1 2 * Division of Neurology, Children's Memorial Hospital, Chicago, IL Departments of Pediatrics and Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL Correspondence: Dr. J. Gordon Millichap, E-mail: jgmillichap@northwestern.edu 08 1998 01 05 2016 12 8 64 64 Copyright: © 1998 The Author(s) 1998 This work is licensed under the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Absence of the superior labial frenulum in holoprosencephaly: a new diagnostic sign

Absence of the superior labial frenulum is reported in 88% of 17 consecutive cases of holoprosencephaly examined at St Christopher’s Hospital for Children, Philadelphia, PA.

 Absence of the Superior Labial Frenulum Midline Facial Abnormalities Holoprosencephaly

Absence of the superior labial frenulum is reported in 88% of 17 consecutive cases of holoprosencephaly examined at St Christopher’s Hospital for Children, Philadelphia, PA. Brain imaging is recommended in children with this anomaly. Patients with midline facial abnormalities such as hypotelorism, smooth philtrum, or single central incisor should be examined for absent frenulum. [1]

COMMENT. Absence of the superior labial frenulum may be added to the spectrum of midline anomalies characteristic of the holoprosencephaly sequence.

Martin RA Jones KL Absence of the superior labial frenulum in holoprosencephaly: a new diagnostic sign J Pediatr 1998 Jul 133 1 151 153 10.1016/S0022-3476(98)70198-2 9672532