1043-3155 Pediatr Neurol Briefs pedneurbriefs Pediatr Neurol Briefs Pediatric Neurology Briefs Pediatr Neurol Briefs 2166-6482 1043-3155 2166-3155 Pediatric Neurology Briefs Publishers Chicago, IL, USA PNB-12-40-b 10.15844/pedneurbriefs-12-5-14 Attention Deficit Disorders Neurology Pediatrics Nervous System Diseases Child Development Brain Diseases Neurosurgery Child Infant Assessment of Adderall in ADHD http://orcid.org/0000-0002-0173-7931 Millichap J. Gordon MD 1 2 * Division of Neurology, Children's Memorial Hospital, Chicago, IL Departments of Pediatrics and Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL Correspondence: Dr. J. Gordon Millichap, E-mail: jgmillichap@northwestern.edu 05 1998 01 05 2016 12 5 40 40 Copyright: © 1998 The Author(s) 1998 This work is licensed under the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Analog classroom assessment of Adderall in children with ADHD

The time course effects of four doses of Adderall® (5, 10, 15, and 20 mg) were compared to placebo and a single dose of methylphenidate in a randomized, double-blind, crossover study of 30 children with attention deficit hyperactivity disorder (ADHD) treated at the Child Development Center, University of California, Irvine.

 Methylphenidate Attention Deficit Hyperactivity Disorder Anorexia

The time course effects of four doses of Adderall® (5, 10, 15, and 20 mg) were compared to placebo and a single dose of methylphenidate in a randomized, double-blind, crossover study of 30 children with attention deficit hyperactivity disorder (ADHD) treated at the Child Development Center, University of California, Irvine. A capsule was given AM and time-response and dose-response were assessed every 1.5 hours through the day, using subjective teacher ratings of attention, and objective math test scores at each classroom session. Significant effects were observed by 1.5 hours with doses of Adderal above 5 mg, and time of peak effects and duration of action increased with the dose. From 5 to 20 mg, the duration of action ranged from 3.5 hrs to 6.4 hrs. Side effects showing a dose-related increase after Adderal adminstration included picking at skin or fingers, appetite loss, and trouble sleeping. Dosage was adjusted in 5 subjects, and 2 elected to withdraw from the trial, one with anorexia (20 mg dose) and one with anorexia, “tearful, sad, depressed“ and “dull, tired, listless“ complaints (10 mg dose). Adderal is recommended in treatment of ADHD. [1]

Swanson JM Wigal S Greenhill LL Browne R Waslik B Lerner M Analog classroom assessment of Adderall in children with ADHD J Am Acad Child Adolesc Psychiatry 1998 May 37 5 519 26 10.1097/00004583-199805000-00014 9585654