1043-3155 Pediatr Neurol Briefs pedneurbriefs Pediatr Neurol Briefs Pediatric Neurology Briefs Pediatr Neurol Briefs 2166-6482 1043-3155 2166-3155 Pediatric Neurology Briefs Publishers Chicago, IL, USA PNB-12-26-b 10.15844/pedneurbriefs-12-4-3 Paroxysmal Disorders Neurology Pediatrics Nervous System Diseases Child Development Brain Diseases Neurosurgery Child Infant Dual Etiology of Rasmussen’s Syndrome http://orcid.org/0000-0002-0173-7931 Millichap J. Gordon MD 1 2 * Division of Neurology, Children's Memorial Hospital, Chicago, IL Departments of Pediatrics and Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL Correspondence: Dr. J. Gordon Millichap, E-mail: jgmillichap@northwestern.edu 04 1998 01 05 2016 12 4 26 27 Copyright: © 1998 The Author(s) 1998 This work is licensed under the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Double pathology in Rasmussen’s syndrome. A window on the etiology?

Five patients with Rasmussen’s syndrome reported from the Montreal Neurological Institute had the typical findings of chronic encephalitis together with tuberous sclerosis, tumor, or vascular abnormality discovered on pathological examination of tissue removed at operation.

 Rasmussen’s Syndrome Vascular Abnormality Dual Pathologies

Five patients with Rasmussen’s syndrome reported from the Montreal Neurological Institute had the typical findings of chronic encephalitis together with tuberous sclerosis, tumor, or vascular abnormality discovered on pathological examination of tissue removed at operation. Dual pathologies were found in 10% of the patients in the authors’ series. [1]

COMMENT. Rasmussen’s syndrome of focal seizures and progressive hemiparesis begins in early childhood, is often preceded by a minor febrile and probable viral illness, and is manifested by epilepsia partialis continua and intellectual deterioration. Short-term reduction in seizure frequency has been reported following IV immunoglobulin and long-term oral prednisolone treatments at the Montreal Neurological Institute. (See Progress in Pediatric Neurology III, 1997;p127).

Hart YM Andermann F Robitaille Y Laxer KD Rasmussen T Davis R Double pathology in Rasmussen’s syndrome. A window on the etiology? Neurology 1998 Mar 50 3 731 735 10.1212/WNL.50.3.731 9521265