1043-3155 Pediatr Neurol Briefs pedneurbriefs Pediatr Neurol Briefs Pediatric Neurology Briefs Pediatr Neurol Briefs 2166-6482 1043-3155 2166-3155 Pediatric Neurology Briefs Publishers Chicago, IL, USA PNB-12-19-b 10.15844/pedneurbriefs-12-3-4 Seizure Disorders Neurology Pediatrics Nervous System Diseases Child Development Brain Diseases Neurosurgery Child Infant Lamotrigine-Induced Aggressive Behavior http://orcid.org/0000-0002-0173-7931 Millichap J. Gordon MD 1 2 * Division of Neurology, Children's Memorial Hospital, Chicago, IL Departments of Pediatrics and Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL Correspondence: Dr. J. Gordon Millichap, E-mail: jgmillichap@northwestern.edu 03 1998 01 05 2016 12 3 19 19 Copyright: © 1998 The Author(s) 1998 This work is licensed under the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Aggressive behaviour in intellectually challenged patients with epilepsy treated with lamotrigine

The response and behavioral profiles of 19 intellectually impaired adults, aged 17-54 years, following treatment with lamotrigine (LTG) as adjunctive therapy for uncontrolled epilepsy are reported from the Epilepsy Research & Services, Chatswood, Australia.

 Intellectually Impaired Adults Lamotrigine Knocking Over Furniture

The response and behavioral profiles of 19 intellectually impaired adults, aged 17-54 years, following treatment with lamotrigine (LTG) as adjunctive therapy for uncontrolled epilepsy are reported from the Epilepsy Research & Services, Chatswood, Australia. Aggressive behavior and violence were provoked in 9 (47%) patients within less than one month of the introduction of LTG, and 5 required complete withdrawal of the drug. Changes in behavior ranged from shouting, slamming doors, or knocking over furniture to attacks on staff and other residents of the institutions. [1]

COMMENT. The behavior of intellectually impaired patients with epilepsy should be closely monitored when lamotrigine is used as adjunctive therapy for uncontrolled seizures. Violent aggression may be provoked and may require withdrawal of the drug.

Beran RG Gibson RJ Aggressive behaviour in intellectually challenged patients with epilepsy treated with lamotrigine Epilepsia 1998 Mar 39 3 280 2 10.1111/j.1528-1157.1998.tb01373.x 9578045