1043-3155 Pediatr Neurol Briefs pedneurbriefs Pediatr Neurol Briefs Pediatric Neurology Briefs Pediatr Neurol Briefs 2166-6482 1043-3155 2166-3155 Pediatric Neurology Briefs Publishers Chicago, IL, USA PNB-12-80-a 10.15844/pedneurbriefs-12-10-12 Attention Deficit and Learning Disorders Neurology Pediatrics Nervous System Diseases Child Development Brain Diseases Neurosurgery Child Infant Frontal Lobe Infarction and Cognitive Deficits http://orcid.org/0000-0002-0173-7931 Millichap J. Gordon MD 1 2 * Division of Neurology, Children's Memorial Hospital, Chicago, IL Departments of Pediatrics and Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL Correspondence: Dr. J. Gordon Millichap, E-mail: jgmillichap@northwestern.edu 10 1998 01 05 2016 12 10 80 80 Copyright: © 1998 The Author(s) 1998 This work is licensed under the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Cognitive deficits associated with frontal-lobe infarction in children with sickle cell disease

Cognitive deficits associated with frontal-lobe infarction in children with sickle cell disease (SCD) were examined at the Institute of Child Health, London, UK.

 Frontal-Lobe Infarction Sickle Cell Disease Wisconsin Card Sorting Test

Cognitive deficits associated with frontal-lobe infarction in children with sickle cell disease (SCD) were examined at the Institute of Child Health, London, UK. Of 41 with SCD who had MRIs, 5 with stroke symptoms had large frontal lobe (FL) infarcts, and 4 without symptoms had smaller FL infarcts. Those with stroke had significant impairments of IQ, memory, and FL function, on the Wisconsin Card Sorting Test (WCST), and those with covert infarction had lesser degrees of cognitive impairment. [1]

COMMENT. Covert infarcts in the frontal lobes may be defined by MRI in 10% of children with sickle cell anemia. The neurologic examination may be normal but cognitive tests may uncover deficits in IQ, memory, and frontal lobe function.

Watkins KE Hewes DKM Connelly A Kendall BE Kingsley DP Evans JE Cognitive deficits associated with frontal-lobe infarction in children with sickle cell disease Dev Med Child Neurol 1998 Aug 40 8 536 543 10.1111/j.1469-8749.1998.tb15412.x 9746006