1043-3155 Pediatr Neurol Briefs pedneurbriefs Pediatr Neurol Briefs Pediatric Neurology Briefs Pediatr Neurol Briefs 2166-6482 1043-3155 2166-3155 Pediatric Neurology Briefs Publishers Chicago, IL, USA PNB-11-48-a 10.15844/pedneurbriefs-11-6-13 Brain Neoplasms Neurology Pediatrics Nervous System Diseases Child Development Brain Diseases Neurosurgery Child Infant Etoposide Therapy for Recurrent Gliomas http://orcid.org/0000-0002-0173-7931 Millichap J. Gordon MD 1 2 * Division of Neurology, Children's Memorial Hospital, Chicago, IL Departments of Pediatrics and Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL Correspondence: Dr. J. Gordon Millichap, E-mail: jgmillichap@northwestern.edu 06 1997 01 05 2016 11 6 48 48 Copyright: © 1997 The Author(s) 1997 This work is licensed under the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Recurrent supratentorial malignant gliomas in children. Long-term salvage therapy with oral etoposide

The efficacy and toxicity of long-term salvage chemotherapy with oral etoposide was studied in 14 children with recurrent supratentorial gliomas at the Department of Neurosciences, University of California, San Diego.

 Etoposide Salvage Therapy Recurrent Malignant Supratentorial Gliomas

The efficacy and toxicity of long-term salvage chemotherapy with oral etoposide was studied in 14 children with recurrent supratentorial gliomas at the Department of Neurosciences, University of California, San Diego. All children had received radiotherapy and nitrosourea chemotherapies previously. MRI showed either a partial response or stable disease over a median duration of 8 months in 7 (50%). Toxic effects included alopecia (8 children), diarrhea (6), weight loss (4), anemia (4), neutropenia (4), and thrombocytopenia (4). [1]

COMMENT. Etoposide appears to be of some value in the salvage therapy of recurrent malignant supratentorial gliomas, and its toxicity is relatively low. This agent is also of value in the treatment of recurrent cerebellar gliomas. [2]

Chamberlain MC Recurrent supratentorial malignant gliomas in children. Long-term salvage therapy with oral etoposide Arch Neurol 1997 May 54 4 554 558 10.1001/archneur.1997.00550170036012 9152112 Chamberlain MC Recurrent cerebellar gliomas: salvage therapy with oral etoposide J Child Neurol 1997 Apr 12 3 200 204 10.1177/088307389701200309 9130095