1043-3155 Pediatr Neurol Briefs pedneurbriefs Pediatr Neurol Briefs Pediatric Neurology Briefs Pediatr Neurol Briefs 2166-6482 1043-3155 2166-3155 Pediatric Neurology Briefs Publishers Chicago, IL, USA PNB-11-38-b 10.15844/pedneurbriefs-11-5-11 Tourette Syndrome Neurology Pediatrics Nervous System Diseases Child Development Brain Diseases Neurosurgery Child Infant Metabolic Anatomy of Tourette’s Syndrome http://orcid.org/0000-0002-0173-7931 Millichap J. Gordon MD 1 2 * Division of Neurology, Children's Memorial Hospital, Chicago, IL Departments of Pediatrics and Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL Correspondence: Dr. J. Gordon Millichap, E-mail: jgmillichap@northwestern.edu 05 1997 01 05 2016 11 5 38 39 Copyright: © 1997 The Author(s) 1997 This work is licensed under the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The metabolic anatomy of Tourette’s syndrome

A Scaled Subprofile Statistical Model (SSM) of regional metabolic covariation was employed to identify functional brain networks in 10 Tourette syndrome (TS) patients (mean age, 41 years), with 10 normal volunteers as controls, in a study at North Shore University Hospital, Manhasset, New York.

 Subprofile Statistical Model Tourette Syndrome Basal Ganglia-Thalamic

A Scaled Subprofile Statistical Model (SSM) of regional metabolic covariation was employed to identify functional brain networks in 10 Tourette syndrome (TS) patients (mean age, 41 years), with 10 normal volunteers as controls, in a study at North Shore University Hospital, Manhasset, New York. Quantitative fluorodeoxyglucose (FDG) and PET were used to calculate global and regional rates of glucose metabolism. While global glucose metabolic rates were normal in TS patients, SSM analysis identified bilateral metabolic increases in lateral premotor and supplementary motor cortex and midbrain, and decreases in caudate and thalamic metabolism. TS patients have a nonspecific pattern of increased motor cortical activity common to other hyperkinetic disorders, and a specific brain network involving reduced activity of limbic basal ganglia-thalamocortical projections. [1]

COMMENT. Two independent brain networks are identified in patients with Tourette syndrome: 1) increased metabolic activity of motor cortical regions involved in execution of movement; and 2) decreased metabolic activity in basal ganglia-thalamic areas governing TS global scale severity.

Eidelberg D Moeller JR Antonini A Kazumata K Dhawan V Budman C The metabolic anatomy of Tourette’s syndrome Neurology 1997 Apr 48 4 927 934 10.1212/WNL.48.4.927 9109879