1043-3155 Pediatr Neurol Briefs pedneurbriefs Pediatr Neurol Briefs Pediatric Neurology Briefs Pediatr Neurol Briefs 2166-6482 1043-3155 2166-3155 Pediatric Neurology Briefs Publishers Chicago, IL, USA PNB-11-78-a 10.15844/pedneurbriefs-11-10-10 Seizure Disorders Neurology Pediatrics Nervous System Diseases Child Development Brain Diseases Neurosurgery Child Infant X-Linked Infantile Spasms http://orcid.org/0000-0002-0173-7931 Millichap J. Gordon MD 1 2 * Division of Neurology, Children's Memorial Hospital, Chicago, IL Departments of Pediatrics and Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL Correspondence: Dr. J. Gordon Millichap, E-mail: jgmillichap@northwestern.edu 10 1997 01 05 2016 11 10 78 78 Copyright: © 1997 The Author(s) 1997 This work is licensed under the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The X-linked infantile spasms syndrome (MIM 308350) maps to Xp11.4-Xpter in two pedigrees

Two unrelated families with X-linked infantile spasm syndrome were studied genetically by two-point and multipoint linkage analyses at the University Hospital Gasthuisberg, and Center for Human Genetics, University of Leuven, and University of Antwerp, Belgium.

 X Chromosome X-Linked Infantile Spasm Zonisamide

Two unrelated families with X-linked infantile spasm syndrome were studied genetically by two-point and multipoint linkage analyses at the University Hospital Gasthuisberg, and Center for Human Genetics, University of Leuven, and University of Antwerp, Belgium. The disease gene was located to the distal part of the short arm of the X chromosome, between Xpter and Xp11.4. [1]

COMMENT. West syndrome may rarely occur in families as an X-linked inherited disorder.

Zonisamide (ZNS) for infantile spasms. ZNS monotherapy was effective in the control of spasms in 4 of 11 patients treated at 11 centers in Japan. [2]

Claes S Devriendt K Lagae L Ceulemans B Dom L Casaer P The X-linked infantile spasms syndrome (MIM 308350) maps to Xp11.4-Xpter in two pedigrees Ann Neurol 1997 Sep 42 3 360 4 10.1002/ana.410420313 9307258 Suzuki Y Nagai T Ono J Imai K Otani K Tagawa T Zonisamide monotherapy in newly diagnosed infantile spasms Epilepsia 1997 Sep 38 9 1035 8 10.1111/j.1528-1157.1997.tb01488.x 9579944