Phenytoin and Carbamazepine Teratogenicity

Authors

  • J Gordon Millichap Northwestern University Feinberg School of Medicine

DOI:

https://doi.org/10.15844/pedneurbriefs-11-1-7

Keywords:

Phenytoin Monotherapy, Carbamazepine Monotherapy, Spina Bifida

Abstract

In a prospective, controlled, and blinded study of 36 mother-child pairs exposed to carbamazepine (CBZ) monotherapy, 34 pairs exposed to phenytoin (DPH) monotherapy, and 9 nonmedicated epileptic women and their children, the patterns of malformations in the children exposed to potential teratogenic factors were compared with matched mother-child pairs exposed to nonteratogens, at the Hospital for Sick Children, Toronto, Canada.

Published

1997-01-01

Issue

Section

Antiepileptic Medications