1043-3155 Pediatr Neurol Briefs pedneurbriefs Pediatr Neurol Briefs Pediatric Neurology Briefs Pediatr Neurol Briefs 2166-6482 1043-3155 2166-3155 Pediatric Neurology Briefs Publishers Chicago, IL, USA PNB-11-03-b 10.15844/pedneurbriefs-11-1-5 Seizure Disorders Neurology Pediatrics Nervous System Diseases Child Development Brain Diseases Neurosurgery Child Infant Cortical Hypometabolism in West Syndrome http://orcid.org/0000-0002-0173-7931 Millichap J. Gordon MD 1 2 * Division of Neurology, Children's Memorial Hospital, Chicago, IL Departments of Pediatrics and Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL Correspondence: Dr. J. Gordon Millichap, E-mail: jgmillichap@northwestern.edu 01 1997 01 05 2016 11 1 3 4 Copyright: © 1997 The Author(s) 1997 This work is licensed under the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Cortical hypometabolism and delayed myelination in West syndrome

Serial PET scans and MRIs were performed in 18 infants with West syndrome (WS) to determine the relation between cortical hypometabolism and delayed myelination in a study at Nagoya University School of Medicine, Japan.

 Cortical Hypometabolism West Syndrome Hypometabolism

Serial PET scans and MRIs were performed in 18 infants with West syndrome (WS) to determine the relation between cortical hypometabolism and delayed myelination in a study at Nagoya University School of Medicine, Japan. All 8 patients with symptomatic WS showed hypometabolism at onset, with persistence in 5 at 10 months, whereas only 4 of 10 patients with cryptogenic WS showed hypometabolism at onset and none at age 10 months. Localization of EEG abnormalities at 10 months correlated with the region of hypometabolism in only 2. MRI showed delayed myelination in 2 at onset of epilepsy and in 12 at 10 months. Delayed myelination at 10 months was correlated with hypometabolism. [1]

COMMENT. MRIs repeated at age 10 months may disclose delayed myelination in infants with WS. The delayed myelination is not always explained by ACTH therapy and may reflect the organic brain lesion causing the seizures.

Natsume J Watanabe K Maeda N Kasai K Negoro T Aso K Cortical hypometabolism and delayed myelination in West syndrome Epilepsia 1996 Dec 37 12 1180 1184 10.1111/j.1528-1157.1996.tb00550.x 8956849