1043-3155 Pediatr Neurol Briefs pedneurbriefs Pediatr Neurol Briefs Pediatric Neurology Briefs Pediatr Neurol Briefs 2166-6482 1043-3155 2166-3155 Pediatric Neurology Briefs Publishers Chicago, IL, USA PNB-10-70-a 10.15844/pedneurbriefs-10-9-9 Endocrine Disorders and Cognition Neurology Pediatrics Nervous System Diseases Child Development Brain Diseases Neurosurgery Child Infant Thyroxine-Induced Absences in JME http://orcid.org/0000-0002-0173-7931 Millichap J. Gordon MD 1 2 * Division of Neurology, Children's Memorial Hospital, Chicago, IL Departments of Pediatrics and Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL Correspondence: Dr. J. Gordon Millichap, E-mail: jgmillichap@northwestern.edu 09 1996 01 06 2016 10 9 70 70 Copyright: © 1996 The Author(s) 1996 This work is licensed under the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Thyroxine exacerbates absence seizures in juvenile myoclonic epilepsy

A patient with juvenile myoclonic epilepsy (JME), manifested as absences at age 10 and myoclonic jerking and generalized tonic clonic seizures at age 15, was treated successfully with primidone at the King Fahad National Guard Hospital, Riyadh, Saudi Arabia.

 Juvenile Myoclonic Epilepsy Tonic Clonic Seizures Multispike

A patient with juvenile myoclonic epilepsy (JME), manifested as absences at age 10 and myoclonic jerking and generalized tonic clonic seizures at age 15, was treated successfully with primidone at the King Fahad National Guard Hospital, Riyadh, Saudi Arabia. Absence seizures were provoked by thyroxine 50 mcg daily prescribed at age 35 for a simple goitre associated with normal thyroid function tests. Loss of concentration lasting a few seconds was associated with frequent discharges of sharp, spike, multispike, and slow wave complexes on the EEG. The thyroid levels were slightly elevated compared to initial tests. Absences stopped and the EEG returned to normal after thyroxine was discontinued. [1]

COMMENT. When thyroid hormone is administered in patients with epilepsy, the dose should be monitored carefully and an EEG obtained to examine for subclinical absence seizures requiring additional antiepileptic medication.

Obeid T Awada A al Rajeh S Chaballout A Thyroxine exacerbates absence seizures in juvenile myoclonic epilepsy Neurology 1996 Aug 47 2 605 6 8757055 10.1212/WNL.47.2.605-a