1043-3155 Pediatr Neurol Briefs pedneurbriefs Pediatr Neurol Briefs Pediatric Neurology Briefs Pediatr Neurol Briefs 2166-6482 1043-3155 2166-3155 Pediatric Neurology Briefs Publishers Chicago, IL, USA PNB-10-46-a 10.15844/pedneurbriefs-10-6-7 Anticonvulsant Drug Toxicity Neurology Pediatrics Nervous System Diseases Child Development Brain Diseases Neurosurgery Child Infant Valproate-Induced Lupus Erythematosus http://orcid.org/0000-0002-0173-7931 Millichap J. Gordon MD 1 2 * Division of Neurology, Children's Memorial Hospital, Chicago, IL Departments of Pediatrics and Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL Correspondence: Dr. J. Gordon Millichap, E-mail: jgmillichap@northwestern.edu 06 1996 01 06 2016 10 6 46 46 Copyright: © 1996 The Author(s) 1996 This work is licensed under the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Valproate-induced systemic lupus erythematosus in a patient with partial trisomy of chromosome 9 and epilepsy

A mentally retarded 30-year-old woman with partial trisomy of chromosome 9, suffering from epilepsy since age 11 months, developed systemic lupus erythematosus after one year of treatment with valproate (VPA) and ethosuximide (ESM) at the Clinica Neurologica, Universita di Roma Tor Vergata, Italy.

 Lupus Erythematosus Valproate Ethosuximide

A mentally retarded 30-year-old woman with partial trisomy of chromosome 9, suffering from epilepsy since age 11 months, developed systemic lupus erythematosus after one year of treatment with valproate (VPA) and ethosuximide (ESM) at the Clinica Neurologica, Universita di Roma Tor Vergata, Italy. When prednisone 1 mg/kg/day was administered and VPA gradually discontinued, clinical remission occurred within 10 days. The patient was maintained on ESM without relapse. [1]

COMMENT. This was the fourth reported case of VPA-induced systemic lupus erythematosus. It presented with arthralgia, fever, and fatigue, after prolonged treatment. It resolved rapidly after discontinuing the drug.

Gigli GL Scalise A Pauri F Silvestri G Diomedi M Placidi F Valproate-induced systemic lupus erythematosus in a patient with partial trisomy of chromosome 9 and epilepsy Epilepsia 1996 Jun 37 6 587 588 10.1111/j.1528-1157.1996.tb00614.x 8641238