1043-3155 Pediatr Neurol Briefs pedneurbriefs Pediatr Neurol Briefs Pediatric Neurology Briefs Pediatr Neurol Briefs 2166-6482 1043-3155 2166-3155 Pediatric Neurology Briefs Publishers Chicago, IL, USA PNB-10-44 10.15844/pedneurbriefs-10-6-4 Toxic Disorders Neurology Pediatrics Nervous System Diseases Child Development Brain Diseases Neurosurgery Child Infant CNS Irradiation Effects on Puberty and Growth http://orcid.org/0000-0002-0173-7931 Millichap J. Gordon MD 1 2 * Division of Neurology, Children's Memorial Hospital, Chicago, IL Departments of Pediatrics and Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL Correspondence: Dr. J. Gordon Millichap, E-mail: jgmillichap@northwestern.edu 06 1996 01 06 2016 10 6 44 45 Copyright: © 1996 The Author(s) 1996 This work is licensed under the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Age at onset of puberty following high-dose central nervous system radiation therapy

The relation between age at irradiation, sex, and age at puberty onset was determined in 36 children treated with high-dose irradiation for tumors anatomically distant from the hypothalamic-pituitary region at the New York University Medical Center, St Luke’s/Roosevelt Hospital, and Memorial Sloan Kettering Cancer Center, New York.

 Cranial Irradiation Puberty Acute Lymphocytic Leukemia

The relation between age at irradiation, sex, and age at puberty onset was determined in 36 children treated with high-dose irradiation for tumors anatomically distant from the hypothalamic-pituitary region at the New York University Medical Center, St Luke’s/Roosevelt Hospital, and Memorial Sloan Kettering Cancer Center, New York. Twenty six also received chemotherapy. Age at onset of puberty and pubarche was significantly earlier in girls but not in boys. The mean age at onset of puberty in both boys and girls was linearly correlated with age at diagnosis and irradiation, and was inversely related to body weight. [1]

COMMENT. High dose cranial irradiation may cause precocious puberty in girls, particularly in those who are overweight.

High-dose methotrexate for acute lymphocytic leukemia in young children did not cause neurological abnormalities or MRI changes in a study of 12 children treated at the University Hospital of Tronheim, Norway [2]. Some previous studies have demonstrated reversible acute and subacute neurotoxicity following methotrexate (MTX) therapy for ALL. The possible role of folinic acid rescue in avoiding MTX toxicity needs further study.

Oberfield SE Soranno D Nirenberg A Heller G Allen JC David R Age at onset of puberty following high-dose central nervous system radiation therapy Arch Pediatr Adolesc Med 1996 Jun 150 6 589 592 10.1001/archpedi.1996.02170310023003 8646307 Seidel H Nygaard R Haave I Moe PJ Magnetic resonance imaging and neurological evaluation after treatment with high-dose methotrexate for acute lymphocytic leukaemia in young children Acta Paediatr 1996 Apr 85 4 450 453 10.1111/j.1651-2227.1996.tb14059.x 8740303