1043-3155 Pediatr Neurol Briefs pedneurbriefs Pediatr Neurol Briefs Pediatric Neurology Briefs Pediatr Neurol Briefs 2166-6482 1043-3155 2166-3155 Pediatric Neurology Briefs Publishers Chicago, IL, USA PNB-1-36-a 10.15844/pedneurbriefs-1-5-8 Infectious Diseases Neurology Pediatrics Nervous System Diseases Child Development Brain Diseases Neurosurgery Child Infant Herpes Zoster Ophthalmicus http://orcid.org/0000-0002-0173-7931 Millichap J. Gordon MD 1 2 * Division of Neurology, Children's Memorial Hospital, Chicago, IL Departments of Pediatrics and Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL Correspondence: Dr. J. Gordon Millichap, E-mail: jgmillichap@northwestern.edu 10 1987 01 08 2016 1 5 36 36 Copyright: © 1987 The Author(s) 1987 This work is licensed under the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Infantile herpes zoster ophthalmicus and acute hemiparesis following intrauterine chickenpox

A 17-month-old boy with HZO and delayed contralateral hemiparesis following intrauterine varicella exposure is reported from the Dept of Neurology, Univ Texas Med Sch, Houston, TX.

 Mandibular Divisions Left Basal Ganglia Minimal Right Hemiparesis

A 17-month-old boy with HZO and delayed contralateral hemiparesis following intrauterine varicella exposure is reported from the Dept of Neurology, Univ Texas Med Sch, Houston, TX. He presented with ataxia and a progressive right-sided weakness. His mother had chicken-pox at 8 months of gestation but he appeared normal at birth. A vesicular rash developed 4 weeks before examination in the distribution of the ophthalmic and mandibular divisions of the left trigeminal nerve. CSF showed mononuclear pleocytosis, CT demonstrated multiple areas of hypodensity in the left basal ganglia, and angiography revealed occlusion of the left lenticulostriate arteries. Treatment with Acyclovir for 10 days was followed by recovery except for minimal right hemiparesis [1]. Passive immunization of susceptible women exposed to varicella is recommended to reduce the risks of maternal and fetal varicella. The determination of varicella zoster virus membrane antigen or equivalent anti-varicella antibody status in pregnant women exposed to varicella is a rapid, satisfactory method for determining who should receive varicella immunoglobulin passive immunization. [2]

COMMENT: The authors cited only one similar previous case in a child, a 7-year-old boy. Delayed focal cerebral angiitis and infarction may occur after an interval of days to months between HZO and neurologic complications in adults. Passive immunization of exposed susceptible women reduces risks of maternal and fetal varicella. [2]

 Leis AA Butler IJ Infantile herpes zoster ophthalmicus and acute hemiparesis following intrauterine chickenpox Neurology 1987 Sep 37 9 1537 8 3498130 10.1212/WNL.37.9.1537 McGregor JA Mark S Crawford GP Levin MJ Varicella zoster antibody testing in the care of pregnant women exposed to varicella Am J Obstet Gynecol 1987 Aug 157 2 281 4 3039845 10.1016/S0002-9378(87)80323-X